Aron Weller

Department of Psychology and the Gonda Brain Research Center Bar Ilan University
Bar Ilan University

Fields of interest:

Major research theme is epigenetic: searching for neurochemical mechanisms at sensitive developmental periods that may “program” and underlie the risk for unhealthy development. Current research examines, separately: a) emotion regulation, using animal models of depression and anxiety, and b) intake and body-weight regulation, using animal models of binge eating, overeating and obesity. Recent focus: Epigenetic mechanisms of trans-generational obesity and “resistance” versus “susceptibility” to obesity.

Recent publications:

Bekker, L., Barnea, R., Brauner, A., & Weller, A. (2014). Adolescent rats are more prone to binge eating behavior: A study of age and obesity as risk factors. Behavioural Brain Research, 270, 108-111.

Marco, A. Kisliouk, T., Tabachnik, T., Meiri, N. & Weller, A. (2014). Overweight and CpG methylation of the Pomc promoter in offspring to high fat diet fed dams are not ‘reprogrammed’ by regular chow diet in rats. The FASEB Journal, 28, 4148-4157.

Barnea, R., Bekker, L., Zifman, N., Marco, A., Yadid, G. & Weller, A. (2015). Trait and state binge eating predispose towards cocaine craving. Addiction Biology, Jan 2017, 22, 163-171. doi: 10.1111/adb.12315. Epub 2015 Sep 30. Version of Record online: 30 SEP 2015.

Zalsman, G, Gutman, A, Shbiro, L., Rosenan, R., Mann, J.J., & Weller, A. (2015). Genetic vulnerability, timing of short-term stress and mood regulation: A rodent diffusion tensor imaging study.  European Neuropsychopharmacology, 25, 2075-2085.

Taler, M., Vered, I., Globus, R., Shbiro, L., Weizman, A., Weller, A. & Gil-Ad, I. (2016). Attenuated weight gain with the novel analog of olanzapine linked to sarcosinyl moiety (PGW5) compared to olanzapine. Journal of Molecular Neuroscience, 58, 66-73.

Shoval, G., Shbiro, L., Hershkovitz, L., Hazut, N., Zalsman, G., Mechoulam, R. & Weller, A. (2016). Pro-hedonic effect of cannabidiol in a rat model for depression. Neuropsychobiology, 73,123-129.

Arnon, L., Hazut, N., Tabachnick, T., Weller, A. & Koren, L. (2016). Maternal testosterone and reproductive outcome in a rat model for obesity. Theriogenology, 86, 1042-1047.

Marco, A., Kisliouk, T., Tabachnik, T., Weller, A. & Meiri, M. (2016). DNA CpG methylation (5mC) and its modification (5hmC) alter histone post-translational modifications at the Pomc promoter, affecting the impact of perinatal diet on leanness and obesity of the offspring. Diabetes, 65, 2258-2267.

Zalsman, G, Weller, A., Shbiro, L., Barzilay, R., Gutman, A., Weizman, A., Mann, J.J., Wasserman, J. & Wasserman, D. (2016). Fiber tract analysis using Diffusion Tensor Imaging reveals aberrant connectivity in a rat model for depression. The World Journal of Biological Psychiatry, 18, 615-623, 2017. doi: 10.1080/15622975.2016.1190866. Epub 2016 Jul 7.

Tabachnik, T., Kisliouk, T., Marco, A., Meiri, N. & Weller, A. (2017). Thyroid hormone-dependent epigenetic regulation of melanocortin 4 receptor levels in female offspring of obese rats. Endocrinology, 158, 842-851.

Kim, Y.J., Schroeder, M., Liang, N.C., Moran, T.H., Weller, A. and Bi, S. (2017). Effects of early postnatal environment on hypothalamic gene expression in OLETF rats. PLOS ONE, 12(6):e0178428. doi: 10.1371/journal.pone.0178428.

Moshe, L., Bekker, L. & Weller, A. (2017). A potential animal model of maladaptive palatable food consumption followed by delayed discomfort. Frontiers in Neuroscience, 11:377. doi: 10.3389/fnins.2017.00377.

Lotan, A., Lifschytz, T., Wolf, G., Keller, S., Ben-Ari, H., Tatarsky, P., Pillar, N., Oved, K., Sharabany, J., Kreizel-Marzel, T., Matsumoto, T., Yamawaki, Y., Mernick, B., Avidan, E., Yamawaki, S., Weller, A., Shomron, N. & Lerer, B. (2017). Differential effects of chronic stress in young-adult and old female mice: Cognitive-behavioral manifestations and neurobiological correlates. Molecular Psychiatry, doi: 10.1038/mp.2017.237.