Fields of interest
Diagnostic toxicology, veterinary medicine, cancer biology, oxidative stress
Sobhakumari A, Orcutt KP, Love-Homan L, Kowalski CE, Parsons AD, Knudson CM, Simons AL.2-Deoxy-d-glucose Suppresses the In Vivo Antitumor Efficacy of Erlotinib in Head and Neck Squamous Cell Carcinoma Cells. Oncology Research. 2016. 24(1): 55-64.
Yu W-N, Nogueira V, Sobhakumari A, Patra KC, Bhaskar PT, Hay N. Systemic Akt1 deletion after tumor onset in p53−/− mice increases lifespan and regresses thymic lymphoma emulating p53 restoration. Cell reports. 2015. 12(4):610-621. doi:10.1016/j.celrep.2015.06.057.
Sobhakumari A, Schickling B, Love-Homan L, Raeburn A, Fletcher EV, Case AJ, Domann FE, Miller FJ Jr, Simons AL. Erlotinib induces cytoprotective autophagy via NOX4 in head and neck cancer cells. Toxicology and Applied Pharmacology. 2013. 272(3):736 – 45.
Fletcher EV, Love-Homan L, Sobhakumari A, Fedderson C, Goel A, Simons AL. Epidermal Growth Factor Receptor inhibition induces pro-inflammatory cytokines via NOX4 in head and neck cancer cells. Molecular Cancer Research. 2013.11(12):1574 – 84.
Sobhakumari A, Love-Homan L, Fletcher EV, Martin SM, Parsons AP, Spitz DR, Knudson CM, Simons AL. Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism. PLoSOne. 2012.7(10):e48175.
Orcutt KP, Parsons AD, Sibenaller ZA, Scarbrough PM, Zhu Y, Sobhakumari A, Wilke WW, Kalen AL, Goswami P, Miller FJ Jr, Spitz DR, Simons AL. Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4. Cancer Research. 2011.71(11):3932 – 40.
Nandakumar P, Sreekumar KP, Sobhakumari A and Sheeba AP. Evaluation of cell-mediated immune responses to phytohaemagglutinin-M as a marker trait for neonatal diseases in goat kids, Indian Journal of Comparative Microbiology Imunology and Infectious Diseases. 2006.27(2):94 – 96.