Beatrice D’Orsi

Post-doctoral Researcher, Casual lecturer and supervisor
Physiology and Medical Physics
Royal College of Surgeons in Ireland
E-mail: beatricedorsi@rcsi.ie
Page: http://www.rcsi.ie

Fields of interest

Neuroscience and neurological disorders, cell death, Bcl-2 family proteins, calcium homeostasis, mitochondrial bioenegergetics

Recent publications

  1. D’Orsi B, Mateyka J, Prehn JH. Control of mitochondrial physiology and cell death by the Bcl-2 family proteins Bax and Bok. J Neurochem Intern. 2017. In press.
  2. D’Orsi B, Engel T, Pfeiffer S, Nandi S, Kaufmann T, Henshall DC, Prehn JH. BokIs Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury. J Neurosci. 2016 Apr 20;36 (16):4564-78. PMID: 27098698.
  3. Connolly NM, D’Orsi B, Monsefi N, Huber HJ, Prehn JH. Computational Analysis of AMPK-Mediated Neuroprotection Suggests Acute Excitotoxic Bioenergetics and Glucose Dynamics Are Regulated by a Minimal Set of Critical Reactions. PLoS One. 2016 Feb 3;11(2):e0148326. PMID: 26840769.
  4. Martin NA, Bonner H, Elkjær ML, D’Orsi B, Chen G, König HG, Svensson M, Deierborg T, Pfeiffer S, Prehn JH, Lambertsen KL. BID Mediates Oxygen-Glucose Deprivation-Induced Neuronal Injury in Organotypic Hippocampal Slice Cultures and Modulates Tissue Inflammation in a Transient Focal Cerebral Ischemia Model without Changing Lesion Volume. Front Cell Neurosci. 2016 Feb 3;10:14. PMID: 26869884.
  5. D’Orsi B, Kilbride SM, Chen G, Perez Alvarez S, Bonner HP, Pfeiffer S, Plesnila N, Engel T, Henshall DC, Düssmann H, Prehn JH. Bax regulates neuronal Ca2+ J Neurosci. 2015 Jan 28;35(4):1706-22. PMID: 25632145.
  6. Andreazzoli M, Gestri G, Landi E, D’Orsi B, Barilari M, Iervolino A, Vitiello M, Wilson SW, Dente L. Kidins220/ARMS interacts with Pdzrn3, a protein containing multiple binding domains. 2012 May 15. PMID: 22609016.
  7. D’Orsi B, Bonner H, Tuffy LP, Düssmann H, Woods I, Courtney MJ, Ward MW, Prehn JH. Calpains Are Downstream Effectors of bax-Dependent Excitotoxic Apoptosis. J Neurosci. 2012 Feb 1;32(5):1847-58. PMID: 22302823.
  8. Dolga AM, Terpolilli N, Kepura F, Nijholt IM, Knaus HG, D’Orsi B, Prehn JH, Eisel UL, Plant T, Plesnila N, Culmsee C. KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia. Cell Death Dis. 2011 Apr 21; 2:e147. PMID: 21509037.
  9. Tuffy LP, Concannon CG, D’Orsi B, King MA, Woods I, Huber HJ, Ward MW, Prehn JH. Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition. Mol Cell Biol. 2010 Dec; 30(23):5484-501. PMID: 20921277.